Luxurious Hotels Celebrate Cinco de Mayo with Innovative Margaritas

From jalapeno and fruit infusions to garden-to-glass herbs and make-your-own-margarita bars, these opulent vacation destinations are rolling out the red carpet for margarita enthusiasts.

Watermelon Puree: At Spencer's by the Sea restaurant at The Reach, sitting on Key West's only natural sand beach, guests can celebrate the holiday with a Watermelon Margarita while taking in sweeping views of the Atlantic. Fresh watermelon puree is matched with Maestro Dobel tequila, agave nectar, and fresh Key West lime juice. With a $32 million renovation in 2008, The Reach, A Waldorf Astoria Resort, dazzles guests with its stunning transformation. This brilliant tropical playground has been redesigned from top to toe, creating a sassy, sexy atmosphere along Key West's only natural beach.

Sneaky Devil: At The Bar at The Spectator Hotel, a southern 1920s speakeasy in Charleston, master mixologist Allen Lancaster offers up a spicy kick on a craft margarita with El Diablo Solapado (Sneaky Devil). Cazadores Reposado and Pineapple-Cilantro Shrub are matched with handmade serrano pepper honey, Tepache pineapple liqueur and fresh lime juice. With a Roaring Twenties, guests will be enchanted by the personality of The Spectator Hotel: a mix of the captivating charm of the Southern belle, the flair of the flapper, and the elegance of the socialite.

Lemoncello Margarita: Celebrate Cinco de Mayo at the elegant Amway Grand Plaza, Grand Rapids, Michigan, with a contemporary take on a classic margarita. The Golden Sun Margarita combines a mixture of Patron Citronage tequila, Lemoncello, simple syrup, five basil leaves and a splash of lemon, lime and grapefruit juices. After a night of celebration, rise and shine to the soothing and majestic view of the Grand River when you stay in one of the river view rooms. Along with a breathtaking view, these rooms boast a design that reflects both the classic and modern characteristics of the hotel.

Blood Orange Spiced: Hilton San Francisco Union Square's Lobby Bar brings the heat in the last month of blood orange season with Avion tequila, Grand Marnier Orange Liqueur, blood orange juice and freshly squeezed citrus. The sweet and tart flavor and distinctive, dark crimson hue makes it the perfect beverage for citrus lovers. The hotel's idyllic location is custom made for exploring Union Square, the Theater District, Chinatown, Nob Hill and local attractions. Experience stunning skyline views of the City by the Bay from the 46-story Tower 1 building and enjoy the modern luxury from the recently remodeled Skyline Bay View rooms.

Tamarind Margarita: Located off the coast of Puerto Rico, W Retreat & Spa on Vieques Island features a Tamarind WET Margarita for guests to sip by the infinity pool overlooking the Atlantic Ocean. The tangy tamarind fruit adds Puerto Rican flare to the concoction of Jose Cuervo, fresh sour mix, triple sec and orange juice. W Retreat is widely considered as one of the most luxurious resorts in Puerto Rico, as guests find themselves in an undiscovered Caribbean paradise, surrounded by pristine beaches, wild horses and the world's brightest bioluminescent bay. Stylish accommodations have been conceived by Spanish designer Patricia Urquiola.